What does a single substitution actually touch?
Every finished product containing the material, at every concentration. Every specification referencing it. The classification and labelling of anything whose hazard profile shifts. Safety data sheets in each language and market. Dossiers and notifications that stated the previous composition. Allergen and claims statements. Costings. Open purchase orders and any batch in progress against the old specification.
Written out, nobody would attempt that from memory. In practice it's attempted from memory constantly, because the alternative is a fortnight of cross-referencing.
